|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
What is Known: • Renal renin-angiotensin system (RAS) has several pathophysiologic functions not only in blood pressure regulation but also in pediatric renal disease.
|
27995362 |
2017 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease.
|
17530296 |
2007 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report a novel dominant REN mutation discovered in an individual after forty years of renal disease.
|
28701203 |
2017 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We investigated the renoprotective effects of valsartan according to polymorphisms of the renin-angiotensin system and transforming growth factor-b1 (TGFB1) genes in patients with chronic non-diabetic proteinuric nephropathies.
|
21303424 |
2011 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients.
|
16384824 |
2006 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We determined various cardiovascular hormones of the renin-angiotensin system and angiotensin converting enzyme gene polymorphism in 56 patients with nondiabetic renal diseases who underwent a renal biopsy.
|
10100072 |
1999 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, our data, in this large and ethnically homogeneous group of patients, do not support the hypothesis that these genetic variants of the renin-angiotensin system are strongly associated with either nephropathy or hypertension in patients with insulin-dependent or non-insulin-dependent diabetes mellitus.
|
9049480 |
1997 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Thus targeted γ-secretase-based prodrugs developed as substrates for γ-GT/γ-GCT have the potential to selectively control Notch activation in kidney diseases with subsequent regulation of the inflammatory stress response and the renin-angiotensin pathways.
|
28971991 |
2018 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This indicates a protective role for catalase and underscores the importance of the intrarenal renin-angiotensin system in renal disease.
|
20508664 |
2010 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results demonstrated that progressive nephropathy in MI rats was associated with intrarenal activation of the renin-angiotensin-aldosterone system.
|
31228798 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks.
|
23397215 |
2013 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data confirm the key role of the renin-angiotensin system to maintain glomerular filtration rate, and highlight an association between a genetic factor and susceptibility to and prognosis of acute kidney disease.
|
19020433 |
2008 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Therefore, it is urgent to develop a new category of anti-nephropathy medicine directly targeting renin.
|
30308499 |
2018 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The role of the renin-angiotensin-aldosterone system in the pathophysiology of hypertension, and cardiovascular and kidney diseases is well known and the renin-angiotensin-aldosterone system is a major regulator of blood pressure through its effect on body fluids and electrolyte homeostasis.
|
31472818 |
2019 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The progression of kidney disease in some patients with type 2 diabetes mellitus may not be adequately suppressed by renin-angiotensin system inhibitors.
|
31248950 |
2019 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The present study examined the role of (pro)renin receptor (PRR) in pathogenesis of albumin overload (AO)-induced nephropathy and activation of the intrarenal renin-angiotensin system (RAS) in rats.
|
29846109 |
2018 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The objective of this study was dual: to investigate whether mice overexpressing renin could mimic the kinetics and the physiopathological characteristics of hypertension-induced renal disease and to identify cellular and/or molecular events characterizing the different steps of the progression of CKD.
|
23300650 |
2012 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The levels of the full-length form of the (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), may be reduced in the membranes of kidneys in renal diseases.
|
30843967 |
2019 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The involvement of renin-angiotensin system (RAS) gene polymorphisms in the pathogenesis of nephropathy has been described predominantly in Caucasian populations.
|
11200871 |
2001 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The influence of renin-angiotensin system genotypes on the antiproteinuric response to high doses of olmesartan in non-diabetic proteinuric nephropathies.
|
24241364 |
2013 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The importance of the RAS in the development and pathogenesis of cardiovascular, hypertensive and kidney diseases has now been firmly established in clinical trials and practice using renin inhibitors, angiotensin-converting enzyme (ACE) inhibitors, type 1 (AT<sub>1</sub>) angiotensin II (ANG II) receptor blockers (ARBs), or aldosterone receptor antagonists as major therapeutic drugs.
|
28619367 |
2017 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The enzyme renin plays a key role in the RAAS cascade and an important role in the development of hypertension and progression of renal disease in ADPKD.
|
26753721 |
2016 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The critical role of the intrarenal renin-angiotensin system (RAS) in the development of kidney disease has been well demonstrated in animal and cell-culture experiments, but evidence from human kidney tissues is lacking.
|
30159797 |
2019 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate the role of the renin-angiotensin system (RAS) in cardiac hypertrophy and renal disorders in THMs.
|
9582107 |
1998 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activity of the renin-angiotensin-aldosterone system (RAAS) is elevated both in the circulation and in the renal tissue of diabetic and nondiabetic nephropathies.
|
15017527 |
2004 |